| Growth Factor Receptor Family |
Description |
| Epidermal Growth Factor Receptors
(EGFR) |
ERBB - Frequently found to be overexpressed in
several tumor types glioblastomas, head/neck squamous cell carcinomas,
breast, oesophageal, urogenital and colorectal tumors.
Experimentation has shown that the antisense approach can reverse the
tumorgenicity of a colon carcinoma cell line.
ERBB-2 - Found in carcinomas of the breast, ovaries, colon, lung,
liver, stomach, kidneys, oesophagus, salivery gland and bladder.
Amplification of ERBB2 occurs in 20% invasive breast carcinomas. It
increases the growth rate of breast carcinomas but not their metastatic
potential.
ERBB-3 - High expression of ERBB3 correlated with the presence of lymph
node metastasis.
ERBB-4 |
| Insulin Like Receptors
(InsulinR) |
IGFI - Primary Breast Tumors express high
levels of IGFI receptor. Antisense RNS to the IGFI receptor was
shown to inhibit growth of human melanoma and glioma in nude mice.
In the absence of IGFI receptor a large fraction of cells may die through
apoptosis, preventing efficient tumor growth.
IRR, Ros, Ltk |
| Platelet-Derived Growth Factor Receptors
(PDGFR) |
PDGF alpha and beta - glioblastomas, chronic
myelomonocytic leukaemia.
c-KIT/SCFR - (Stem Cell Factor Receptor) GIST
CSF1 - Found in patients with myelodysplastic syndrome.
Flk2/Flt3 |
| Fibroblast Growth Factor Receptors
(FGFR) |
FGFR-1,FGFR-2, FGFR-3, FGFR-4, Cek2 |
| Neurotrophin Receptor Family |
|
| Angiogenic Receptors |
The growth of solid tumors is absolutely
dependent on angiogenesis. Some tumor cells can release angiogenic
factors but others recruit macrophages. Angiostatin is produced by
certain tumors and inhibits angiogenesis.
FGF - binds to a family of receptors with two or three immunoglobuline
like extracellular domains. Overexpression contributes to growth of
melanomas and some breast cancers..
VEGF - binds to 2 related receptors with seven immunoglobulin like
extracellular domains. |
| Hepatocyte Growth Factor Receptor |
MET - Osteosarcoma, Colorectum, thyroid,
ovaries, stomach, pancreas and hepatocellular carninomas. |
| Cytokine Receptor Family |
|
